The good news is that we know antidepressants can treat major depression, helping millions of people live healthier lives. The bad news is that we don’t really know how they do that. Check out the theories on how antidepressants work in this episode.
Ever wondered whether that little pill actually knows how to fix a broken brain? This episode dives into the surprisingly murky science behind antidepressants, tracing everything from Hippocrates and black bile to modern SSRIs, tricyclics, MAOIs, and the wild world of unregulated supplements. Josh and Chuck unpack why these drugs work even though nobody's fully sure why, what makes each class different (and sometimes hilariously named), and why treating depression is way more complicated than just topping off a chemical shortage.
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