May 16 2023

The Inflammation Theory of Disease

67 min 3 movies discussed
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Not too long ago we thought that germs were the cause of most diseases, leading to germ theory. But when we look at maladies from heart disease to Alzheimer’s one commonality stands out: inflammation. Could it be we’ve found the root cause of all diseases?

AI Summary

# Stuff You Should Know: Inflammation

Josh and Chuck dive deep into the fascinating and scary world of chronic inflammation, exploring how this bodily response that's supposed to protect us has become linked to nearly half of all human deaths worldwide. They break down how acute inflammation—like what happens when you sprain an ankle—is actually healthy and necessary, but when that same process continues long-term without stopping, it becomes a silent killer contributing to everything from heart disease and diabetes to depression, Alzheimer's, and various cancers. The hosts discuss compelling evidence that inflammation might be the root cause rather than just a symptom of these diseases, and they explore how our modern lifestyle and diet create an evolutionary mismatch that keeps our bodies in a constant state of inflammatory alert.


Movies Discussed

Fletch
Fletch
1985 1h 38m
★ 6.7
"that new Fletch movie with John Hamm...It was very under the radar. — Josh and Chuck discuss a recent Fletch movie starring Jon Hamm that appeared on Amazon Prime." — Josh
Hamilton
Hamilton
2025 2h 40m
★ 7.6
"I was inspired by David Diggs. He has a record listening room...he has a record LP vinyl listening room — Josh mentions David Diggs of Hamilton as inspiration for building a record listening room under his staircase." — Josh
The Simpsons
The Simpsons
1989
★ 8.0
"That reminds me of that Simpsons in the House of Horrors...behold, the ravages of age. — Josh references a Treehouse of Horror episode from The Simpsons where Lisa encounters an old lady in a rocking chair." — Josh

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